According to totalfilmcom the best movie bad guy

first_imgAccording to totalfilm.com, the best movie bad guy of all time is The Joker, as played by Heath Ledger. Darth Vader is two. Hannibal Lecter third. Agent Smith from The Matrix is ninth. Gordon Gecko (way way underrated) is 11th. Hans Gruber (see Gecko) comes in 15th. The complete list is here. Not so coincidentally, the list reflects some of my personal favorite movies of all time. No secret; a great bad guy can turn a so-so movie into a great story. That’s why Karlos Dansby going to the Browns isn’t much of a story. There’s not really a bad guy in it.Oh, I got some tweets Tuesday from people who tried to paint Dansby out to be the scoundrel. One tweeter hoped that Dansby can root for the Cardinals in the playoffs while he’s bathing in the Browns’ money. Another suggested he had lost respect for him because he took more money elsewhere. Two tweeters do not make a consensus, but you get the drift. Except I’m not buying this lack of loyalty angle. Dansby is 32 years old and has one last chance to hit the big time before walking away from the game for good. Is it wrong to criticize him for doing what many of us probably would have done ourselves? Yes. Yes it is. So, no bad guy there. What about the Cardinals? Certainly there is an immediate assumption by some (including my co-host) that the Cardinals low-balled their linebacker. Except that doesn’t make any sense. The Cardinals valued him. They spoke, often publically, about wanting him back. They were in a difficult position and everybody knew it, leading Bill Polian to state that he felt sorry for Steve Keim. Karlos Dansby is 32, going to be 33 in November. You can’t pay a premium price for players of that age; I don’t care what they did for you the season prior. You make a fiscally responsible offer and if it’s not good enough you move on and hope your plan B (Kevin Minter) is an adequate replacement. Otherwise you’re stuck in dead-money-hell when that player really gets old. Karlos Dansby did nothing wrong. The Arizona Cardinals did nothing wrong. A story without a bad guy isn’t much of a story. Former Cardinals kicker Phil Dawson retires Top Stories The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo Derrick Hall satisfied with D-backs’ buying and selling Comments   Share   Grace expects Greinke trade to have emotional impactlast_img read more

The breakdown of this brain region may accelerate aging

first_img Sign up for our daily newsletter Get more great content like this delivered right to you! Country Roger Harris/Science Source The breakdown of this brain region may accelerate aging If these sweltering summer days prompt you to reach for a cold drink, you can thank your hypothalamus, a region of the brain that helps us regulate body temperature and other internal conditions. But the region may fail us when we get older. A new study in mice suggests that the hypothalamus promotes aging, hastening physical and mental decline as its stem cells die off.“It’s a pretty stunning paper,” says Charles Mobbs, a neuroendocrinologist at the Icahn School of Medicine at Mount Sinai in New York City. The new aging mechanism “is totally novel and quite unexpected,” adds neuroendocrinologist Marianna Sadagurski of Wayne State University in Detroit, Michigan.Tucked away deep in the brain, the hypothalamus monitors and maintains our blood concentration, our body temperature, and other physiological variables. Researchers have also suspected that it plays a role in aging. The hypothalamus becomes inflamed as we get older, and 4 years ago a team led by neurodendocrinologist Dongsheng Cai of Albert Einstein College of Medicine in New York City showed that quelling this inflammation delays physical deterioration and boosts life span in mice. Email The hypothalamus, a command center deep in the brain, helps control everything from hunger to sleep. center_img In the new study, the team turned its attention to the hypothalamus’s stem cells, which in young animals divide to produce replacements for dead and damaged cells. As mice get older, the scientists found, the number of stem cells in the hypothalamus plunges. By later ages they are “basically all gone,” Cai says.To determine whether this loss promotes aging, researchers tried to speed up the process, genetically altering mice so that stem cells in the hypothalamus died when the animals were dosed with an antiviral drug. Knocking off some 70% of the cells shortened the mice’s lives by about 8%, the team reports today in Nature. The mice’s memory, coordination, and endurance also suffered. Behaviorally, they were like grumpy grandparents, less social and curious than youthful rodents. For example, when researchers put a new object into their cages, control mice spent about twice as long exploring it than did their modified counterparts.Next, the team tried to reverse this deterioration by injecting stem cells into the hypothalami of middle-aged animals. Mice that received the stem cells outlived mice injected with a different type of brain cell by more than 10%, and they retained more of their physical and mental capabilities. In humans, the extra boost could mean a few more years of healthy life, Mobbs notes.Researchers assume the loss of stem cells causes organs and tissues to wear out gradually because they can’t replenish their lost cells. But because injecting stem cells into the mice produced benefits quickly, Cai and his colleagues concluded a faster-acting mechanism was at work.Their suspicions fell on RNA molecules known as microRNAs, which stem cells manufacture and release. These microRNAs ferry messages to other cells, altering which proteins they produce. The researchers found that stem cells from the hypothalamus pump out huge amounts of microRNAs, packaged in tiny containers called exosomes. They also found that injecting mice with microRNA-rich exosomes isolated from cultures of young hypothalamus stem cells slowed the animals’ physical and cognitive breakdown almost as much as injections of stem cells.“The big question is how those microRNAs influence function,” Mobbs says. The molecules could spur other cells to curb inflammation or stress, Cai says, though he isn’t certain how they work. Where the microRNAs exert their effects is also a mystery. Their targets may be other cells in the brain or the spinal cord, but they might also slip into the bloodstream and prod cells elsewhere in the body.The work suggests that protecting or replacing the hypothalamus’s stem cells—or replicating the effects of the microRNAs—could slow aging in humans. It might also be possible to suppress the inflammation that provokes the stem cell die-off, Sadagurski says. She says some current drugs, including the diabetes treatment acarbose, curb inflammation in the hypothalamus and may be worth testing. 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Required fields are indicated by an asterisk (*) By Mitch LeslieJul. 26, 2017 , 1:00 PMlast_img read more